Selective Estrogen Receptor Degraders Therapeutic Market: How Are SERDs Reshaping Endocrine Therapy Beyond the Limitations of Tamoxifen and Aromatase Inhibitors?
Selective estrogen receptor degraders — the next-generation endocrine agents that bind the estrogen receptor and induce its conformational change, ubiquitination, and proteasomal degradation rather than merely blocking estrogen binding — represent the most significant mechanistic advance in hormone receptor-positive breast cancer therapy since the introduction of aromatase...
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